One of the most frequent

2019-08-28

One of the most frequent gene alterations in MM is methylation of the p15 and p16 genes in the 5′ upstream region.

Not all of the biological activities exhibited by progestoge

2019-08-27

Not all of the biological activities exhibited by progestogens (Table 1) are mediated via binding to SRs. For example, the anti-estrogenic action of progestogens in the AXL1717 is due to the progestogen-bound PR suppressing ER gene expression, and consequently the ability of the cell to respond to estrogen.

A genomic DNA sequence was retrieved Scaffold from the fugu

2019-08-26

A genomic DNA sequence was retrieved (Scaffold_30) from the fugu genomic database ( v3.0), which encodes the homolog of CXCL8 of many other vertebrates and specific primers CXCL8F1 and CXCL8R1 () were designed for 3′-RACE and 5′-RACE PCR, respectively.

AM966 A prominent example of such enzyme is

2019-08-24

A prominent example of such enzyme is the proteasome, a highly promising target not only in cancer, but also in inflammatory and autoimmune diseases.

Multi hierarchical structure of

2019-08-23

Multi-hierarchical structure of collagen Protein structure is the foundation of protein functions and properties. It is generally accepted that the protein has biological function only when it has tertiary structure or above.

Support for Cloninger s personality

2019-08-22

Support for Cloninger\'s personality theory comes also from molecular genetic studies. Given the high heritability of personality it is plausible that gene variants explain variance in RD.

The major regulator of radiation sensitivity Tumor cell resi

2019-08-21

The major regulator of radiation sensitivity Tumor cell resistance to radiation is a big issue for radiation therapy, and a major concern of radiation oncologist.

CPH models reported usually as lists of risk

2019-08-20

CPH models, reported usually as lists of risk factors along with their parameters, are prevalent in medical literature.

A prominent example of such enzyme is the proteasome a

2019-08-19

A prominent example of such enzyme is the proteasome, a highly promising target not only in cancer, but also in inflammatory and autoimmune diseases.

In addition to cleaving ubiquitins off modified proteins DUB

2019-08-17

In addition to cleaving ubiquitins off modified proteins, DUBs can also cleave between ubiquitin moieties within a polyubiquitin chain to edit the ubiquitin signal. DUBs employ different strategies to recognize polyubiquitin (Figure 1).

Rationale and hypothesis To discover an allosteric inhibitor

2019-08-16

Rationale and hypothesis To discover an allosteric inhibitor of EGFR, Jia et al. (2016) screened a library of 2.5 million compounds at 1 μM ATP concentration in opposition the purified EGFR L858R/T790M mutant enzyme.

Analysis of DNA fragmentation We followed

2019-08-15

Analysis of DNA fragmentation. We followed a modified Hirt extraction procedure for analysis of DNA fragmentation.

As described above we designed and

2019-08-14

As described above, we designed and synthesized a new 1,4-di-substituted isoquinoline lead compound, and was identified as a ligand with moderate potency for the CRTH2 receptor.

E Ubiquitin Ligases Regulate Central and Peripheral T Cell

2019-08-13

E3 Ubiquitin Ligases Regulate Central and Peripheral T Cell Tolerance During the random process of somatic recombination, T cell receptors (TCRs; see Glossary) that recognize self-antigens are commonly generated.

Hello world!

2018-07-29