In addition to cleaving ubiquitins off modified proteins DUB

2019-08-17

In addition to cleaving ubiquitins off modified proteins, DUBs can also cleave between ubiquitin moieties within a polyubiquitin chain to edit the ubiquitin signal. DUBs employ different strategies to recognize polyubiquitin (Figure 1).

Rationale and hypothesis To discover an allosteric inhibitor

2019-08-16

Rationale and hypothesis To discover an allosteric inhibitor of EGFR, Jia et al. (2016) screened a library of 2.5 million compounds at 1 μM ATP concentration in opposition the purified EGFR L858R/T790M mutant enzyme.

Analysis of DNA fragmentation We followed

2019-08-15

Analysis of DNA fragmentation. We followed a modified Hirt extraction procedure for analysis of DNA fragmentation.

As described above we designed and

2019-08-14

As described above, we designed and synthesized a new 1,4-di-substituted isoquinoline lead compound, and was identified as a ligand with moderate potency for the CRTH2 receptor.

E Ubiquitin Ligases Regulate Central and Peripheral T Cell

2019-08-13

E3 Ubiquitin Ligases Regulate Central and Peripheral T Cell Tolerance During the random process of somatic recombination, T cell receptors (TCRs; see Glossary) that recognize self-antigens are commonly generated.

Hello world!

2018-07-29