• Most studies on d penicillamine induced

  2024-11-04

  

  Most studies on d-penicillamine-induced MG were performed before the discovery that some MG patients have anti-MuSK antibodies. After the identification of the present case, we retrospectively tested the stored frozen sera of ten earlier identified d-penicillamine MG patients with anti-AChR IT-901

• Autophagy is a highly conservative intracellular bulk

  2024-11-01

  

  Autophagy is a highly conservative intracellular bulk degradation process including three major forms namely microautophagy, chaperone-mediated autophagy and macroautophagy. A large number of evidence has depicted a pivotal role for autophagy in the maintenance of cardiac geometry and contractile fu

• There are in contrast many studies demonstrating that sex st

  2024-11-01

  

  There are in contrast many studies demonstrating that sex steroids modulate UMI-77 processing of stimuli related to reproduction and this correlates with the observation that steroid receptors and aromatase are expressed in many brain nuclei that are part of the olfactory, visual and auditory pathw

• Gap19 br Materials and methods br Results br Discussion In t

  2024-11-01

  

  Materials and methods Results Discussion In this study, the orphan receptor GPR25 was cloned from several representative vertebrate species including zebrafish. Although the overall amino Gap19 sequence identity among these species is not high (38–52%), our synteny analysis clearly indicat

• br Concluding Remarks Despite major advances in the developm

  2024-11-01

  

  Concluding Remarks Despite major advances in the development of antibody and small-molecule tumor angiogenesis inhibitors, therapy resistance, both innate and acquired, continues to limit further survival improvements for patients with cancer. Preclinical models of localized primary tumors and me

• Recently the FDA approved the first blood based

  2024-11-01

  

  Recently, the FDA approved the first blood-based test for the detection of EGFR mutations in non-small cell lung cancer patients (http://www.fda.gov) (Voelker, 2016). This allows detection of specific, recurrent mutations, which can help the selection of the patients that could benefit from Erlotini

• In our sequential model for

  2024-11-01

  

  In our sequential model for tau and Aβ deposition, we included the tau deposition in the medial temporal Bax inhibitor peptide V5 in the absence of Aβ deposition, which is a pathological definition of primary age-related tauopathy (PART). Although the tau pathologies in PART and AD are almost ident

• br Author contributions br Financial disclosures br Acknowle

  2024-10-31

  

  Author contributions Financial disclosures Acknowledgements We thank Ms. Eva So for the editorial assistance. This work was supported by grants from the National Natural Science Foundation of China (No. 81622015, 81571042 and 81501143) and the National Basic Research Program of China (No. 2

• OCT also is known as POU F plays an

  2024-10-31

  

  OCT4 (also is known as POU5F1) plays an important role in embryonic stem cell self-renewal, development and reprogram somatic cell into pluripotent stem cell [[5], [6], [7]]. Recently, many studies also find OCT4 promotes the progression of many tumors. For example, Wnt/β-catenin promotes the expans

• In these experiments recordings were performed

  2024-10-31

  

  In these experiments, recordings were performed continuously in the homecage and during the first 5 days of training on a randomized forced alternation T-maze working memory task (Figures 1A, 1B, 3A, and 3B) (Kucewicz et al., 2011). Sleep and wake states were determined by simultaneous recording of

• br Funding br Introduction The interest in the effects

  2024-10-31

  

  Funding Introduction The interest in the effects of endocrine disrupting chemicals (EDCs) in the aquatic environment continues to increase over the past decade, specifically those that act on steroidogenic pathways. EDCs that include synthetic androgenic and estrogenic compounds can severely a

• br Acknowledgments br Introduction Cancer is the leading

  2024-10-31

  

  Acknowledgments Introduction Cancer is the leading cause of mortality in the United States for those between the ages of 40–79 years, surpassing heart diseases by more than 100,000 deaths [1]. The cause of most cancer subtypes remains idiopathic and may arise out of ‘bad luck’ among otherwise

• 94 6 sale IC values were obtained for an expanded version

  2024-10-31

  

  IC50 values were obtained for an expanded version of the fragment library using the previously described mobility shift assay. Subsequently, Ki values were estimated from IC50 values to allow better comparison of the activity against targets which were measured at different substrate concentrations

• In addition to pH regulation by ion counter fluxes acidifica

  2024-10-31

  

  In addition to pH regulation by ion (counter-) fluxes, acidification is regulated by the abundance of V-ATPase on organelles, by the pumping activity of the complex and by proton leakage. In yeast, the V-ATPase VO subunit a is the only subunit expressed in two isoforms termed Stv1p and Vph1p. V-ATPa

• Consistent with a damaging role for increased LOX activity i

  2024-10-31

  

  Consistent with a damaging role for increased 12/15-LOX activity in stroke, systemic administration of the 12/15-LOX inhibitor, LB1, 2 h after permanent focal cerebral ischemia significantly reduced infarct size 24 h after the ischemia, and the treatment group demonstrated improved behavioral and he

14565 records 66/971 page Previous Next First page 上5页 6667686970 下5页 Last page