• PyBOP The important role of miRNAs in cellular differentiati

  2021-05-07

  

  The important role of miRNAs in cellular differentiation has been proposed recently. Previous studies had suggested roles for different miRNAs during osteogenesis [20]. Certain miRNAs could promote osteoblast differentiation, such as miR-194 [20], whereas others could inhibit the cell differentiatio

• Previous studies from our lab looked

  2021-05-07

  

  Previous studies from our lab looked at the effect of interfering with crossover helix interactions in TS-DHFR. One study utilized peptide mimetics of the crossover helix to inhibit wild-type TS-DHFR noncompetitively, and with an IC of 230 μM. A second study used a virtual screening approach to iden

• Cytokines are small secreted proteins

  2021-05-06

  

  Cytokines are small secreted proteins that mediate and regulate immunity, inflammation, and hematopoiesis. They are produced in response to an immune stimulus. Cytokines regulate the intensity and duration of the immune response by stimulating or inhibiting the activation, proliferation, and/or diff

• br Conflict of interest br Acknowledgments We thank Jianru Z

  2021-05-06

  

  Conflict of interest Acknowledgments We thank Jianru Zuo (Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China) for providing fbr11-1 seeds. We are grateful to Carol MacKintosh and the DSTT at the University of Dundee (UK) for anti-RD21 antibodies. This

• For the first time we

  2021-05-06

  

  For the first time, we provide evidence for COMT Val158Met modulation of long-term fear extinction in humans, evident both in cortical (LPP) and autonomic (fear bradycardia) components of the conditioned fear response. We further found that the initial acquisition of fear is related to dispositional

• In Murray Darling rainbowfish confirming the

  2021-05-06

  

  In Murray–Darling rainbowfish, confirming the expected in vivo effects of androgenic progestins could be achieved using short-term exposures and determining expression profiles for androgen-responsive genes, or in longer term exposures by monitoring fecundity or the development of male secondary sex

• The underlying assumption of consolidation

  2021-05-06

  

  The underlying assumption of consolidation/re-consolidation is that the ski or skii receptor activity initiated during the acquisition trial/re-consolidation trial continues to persist briefly after completion of the trial and it is during this post-trial period that immediate post-trial treatments

• br Methods and materials br

  2021-05-06

  

  Methods and materials Results Discussion Many small molecules have been individually explored to enhance endothelial barrier both in vitro and in vivo, including S1P, forskolin, cAMP analogs, ROCK inhibitors, statins, and imatinib [[10], [11], [12],25,26]. In the current study, we applied t

• Just as Dorin et al and

  2021-05-06

  

  Just as Dorin et al. [2] and Nguyen et al. [3] write in regard to their models, our static model can be used to estimate the affinities of Bax inhibitor peptide V5 to albumin and CBG. Dorin et al. [2] estimates the K, but not K, since they find that their model is not particular sensitive towards c

• br Regulation of cadherin switching The downregulation of

  2021-05-06

  

  Regulation of cadherin switching The downregulation of E-cadherin during cadherin switching is induced by multiple mechanisms, including methylation of the E-cadherin promoter and signaling pathways that activate E-cadherin-suppressing transcription factors [[61], [62], [63]]. During the progress

• Cancer patients may develop cachexia a deleterious

  2021-05-06

  

  Cancer patients may develop cachexia, a deleterious wasting syndrome that is associated with muscle atrophy and has an impact on the well-being of patients and on the response to the treatment. Indeed, cachexia is a devastating and often irreversible syndrome observed in up to 80% of cancer patients

• br Materials and methods br Results

  2021-05-06

  

  Materials and methods Results Discussion Innate immunity plays an essential role in the control and elimination of bacterial infection through production of inflammatory cytokines (Liu et al., 2015). Production of inflammatory cytokines requires the recognition of bacterial pathogen-associa

• br E intracellular localization br

  2021-05-06

  

  E1 intracellular localization Regulation of E1 by other post-translational modifications Concluding remarks Acknowledgments We apologize to those whose work was not included because of space considerations or whose papers were unintentionally omitted. We thank Dr Peter Bullock (Tufts Uni

• The knockout mice models of the DNMTs

  2021-05-06

  

  The knockout mice models of the DNMTs gene shed light on understanding the molecular background of male infertility development. Dnmt1−/− causes demethylation of the genome (Lei et al, 1996, Li et al, 1992) (). The Dnmt3a conditional knockout mouse models exhibit spermatogenic arrest at the spermato

• Moreover maintaining the pyrimidine pool is

  2021-05-06

  

  Moreover, maintaining the pyrimidine pool is not the only important role played by DHODHs. In Toxoplasma gondii, for instance, DHODH plays a second essential function [38] possibly coupled to the mitochondrial respiratory activity, where it replenishes ubiquinol levels and prevents reactive oxygen s

14442 records 650/963 page Previous Next First page 上5页 646647648649650 下5页 Last page