• UNC669 Several bacterial functional pathways were

  2022-09-15

  

  Several bacterial functional pathways were observed after DON administration, of which signal transduction, metabolism and genetic information processing displayed the highest levels of enrichment. Importantly, these three pathways were reported to be closely associated with DON's toxicity. Many evi

• Several studies have reported that the genotype

  2022-09-14

  

  Several studies have reported that the genotype and allele frequencies of S267F vary considerably between different study groups and geographical regions (Ezzikouri et al., 2017, Hu et al., 2016, Lee et al., 2017, Li et al., 2014, Pan et al., 2011, Peng et al., 2015, Yang et al., 2016, Zhang et al.,

• br Conclusion Interactions between neurons and

  2022-09-13

  

  Conclusion Interactions between neurons and astrocytes depend on the spatial configuration of their contacts. Therefore, changes of astrocyte morphology may impact various physiological mechanisms ranging from glutamate uptake and potassium homeostasis to modulation of synaptic transmission and p

• br Conclusion Interactions between neurons and

  2022-09-13

  

  Conclusion Interactions between neurons and astrocytes depend on the spatial configuration of their contacts. Therefore, changes of astrocyte morphology may impact various physiological mechanisms ranging from glutamate uptake and potassium homeostasis to modulation of synaptic transmission and p

• While published data around the functional

  2022-09-09

  

  While published data around the functional significance of GPR84 are quite sparse, details of signaling pathways initiated by the receptor are even more limited, including in recombinant systems. In recombinant cells, GPR84 activation reportedly leads to Gi pathway activation, resulting in pertussi

• br Potential endogenous agonists of

  2022-09-09

  

  Potential endogenous agonists of GPR35 The first endogenously produced chemical that was shown to be able to activate GPR35 was the tryptophan metabolite kynurenic Suramin hexasodium salt [8]. When human GPR35 was expressed along with a mixture of promiscuous and chimeric G proteins 9, 10 (Box 1

• Starting from commercially available dioxaspiro decan

  2022-09-09

  

  Starting from commercially available 1,4-dioxaspiro[4.5]decan-8-ol, was prepared by the synthetic sequence illustrated in . Aromatic nucleophilic substitution of 1,4-dioxaspiro[4.5]decan-8-ol, followed by an Cyanine 5-dCTP synthesis catalyzed deprotection efficiently gave . A - enriched mixture of

• cck 1303 A general synthetic pathway to these

  2022-09-09

  

  A general synthetic pathway to these tricyclic structures is described in (detailed procedures can be accessed in the patent application WO 2011/014520 A2). Benzylation of the appropriate ketoester using KHMDS, followed by treatment with DMF-dimethyl acetal yielded the racemic (dimethylamino)-methy

• br Significant efforts are currently focused

  2022-09-09

  

  Significant efforts are currently focused on non-dopaminergic strategies to address the unmet medical needs in schizophrenia, and targeting -methyl--aspartate (NMDA) zingerone mg hypofunction has garnered a great deal of attention., , Elevation of synaptic glycine levels near NMDA-containing syn

• direct renin inhibitors The kinetic data obtained from incub

  2022-09-09

  

  The kinetic data obtained from incubation of 4BAB with GLO1 show that 4BAB does not completely inactivate the enzyme (Figs. 2A and S6a). At low concentrations (4.7 and 14.4μM), 4BAB seemed to follow biphasic kinetics (Fig. 2A); even though regardless of the concentration 4BAB, there was a plateau at

• Heparin and suramin are highly negatively charged molecules

  2022-09-09

  

  Heparin and suramin are highly negatively charged molecules, and they are in this aspect, similar to DNA and likely to compete with DNA by binding to the protein cationic groups [17] (Fig. 1). The inhibitory effect of heparin and suramin on DNA and RNA binding proteins has been described [[18], [19]

• NPE-caged-proton br Conclusion Until recently astrocytes wer

  2022-09-09

  

  Conclusion Until recently, astrocytes were recognized solely for their maintenance role in the regulation of NPE-caged-proton homeostasis. Nowadays, this idea has changed, it is clear that these cells play a crucial role in the regulation of neuronal activity and signal transmission. In particul

• In prostate cancer PCa glucose

  2022-09-09

  

  In prostate cancer (PCa), glucose metabolism plays a major role in progression [14]. Androgens can activate the metabolic regulator AMP-activated kinase (AMPK), promoting oxidative phosphorylation (OXPHOS) [15]. Besides, androgens increase GLUT1 [16], which overproduction has been described in the m

• In general fish has a limited ability for digestion

  2022-09-09

  

  In general, fish has a limited ability for digestion and metabolism of carbohydrate though carbohydrate is the cheapest dietary energy and carbon source to animals and the best candidate for replacing dietary protein (Enes et al., 2009, Kamalam et al., 2017, Wilson, 1994). Furthermore, the analysis

• blasticidin Deregulation of HH signaling pathway

  2022-09-09

  

  Deregulation of HH signaling pathway in epidermal keratinocytes is a primary event leading to the formation of BCC (see above). Overexpression of SHH in HaCaT keratinocytes grown in organotypic cultures induces a basal cell phenotype and increases invasiveness. This behavior is linked to increased E

14127 records 346/942 page Previous Next First page 上5页 346347348349350 下5页 Last page