• Drug resistance development often involves structurally un r

  2025-01-21

  

  Drug resistance development often involves structurally un-related drugs and, specifically both conventional and targeted agents. IGROV-1/Pt1 Hydrocortisone are characterized by resistance to cisplatin and reduced sensitivity to inhibitors of EGF-R and MEK, the up-stream activator of ERK1/2, associ

• The distribution and subcellular localization differs betwee

  2025-01-20

  

  The distribution and subcellular localization differs between the subtypes of mGlu receptors. Most mGlu receptors are broadly expressed in the brain, except for mGlu6, which is restricted to the retina. Some mGlu receptors are additionally found in glial cells, such as mGlu3 and mGlu5 (Aronica et al

• Two major categories of arginase inhibitors have been

  2025-01-20

  

  Two major categories of arginase inhibitors have been distinguished (Fig. 3): the first category comprises synthetic arginase inhibitors, which have been developed from the substrate l-arginine [35]; and the second category includes inhibitors derived from natural products [36]. The category of synt

• br Experimental procedures br Results br Discussion

  2025-01-20

  

  Experimental procedures Results Discussion Major depressive disorder is among the leading causes of disability worldwide (Vos et al., 2015). One of the major causal or exacerbating factors of depression is long term stress or psychological trauma (Liu and Alloy, 2010). Dysregulation of the

• Thio-TEPA Given that the FST protocol

  2025-01-20

  

  Given that the FST protocol for mice does not engage the exposure to a previous stressful session, posits that Agtr1a levels could be kept higher by basal glutamatergic transmission rather than by stressful stimuli as postulated before. To address this possibility, we used the EMBL-EBI Expression At

• Recently rather than predicting categorical variables as

  2025-01-20

  

  Recently, rather than predicting categorical variables as in classification, several studies begin to estimate continuous clinical variables from MRI imaging contrast images. Therefore, instead of classify a subject into binary or multiple pre-determined categories or stages of the disease, regress

• Molecular docking simulations were carried out

  2025-01-18

  

  Molecular docking simulations were carried out for ligands – in the ACE crystal structure (1O86) and DPP4 crystal structure (2G5P). Comparison of the binding mode of – () with enalaprilat (a) in ACE shows that the phenethyl group (–, enalaprilat) occupies the S1 pocket and the adjacent carboxylic CH

• hydroxydopamine OHDA is a selective catecholaminergic neurot

  2025-01-18

  

  6-hydroxydopamine (6-OHDA) is a selective catecholaminergic neurotoxin mainly used to generate lesions in the nigrostriatal pathway in rats (Ungerstedt, 1968). The most common use of 6-OHDA is via unilateral injection into the rat medial forebrain bundle (MFB). DA depletion, nigral DA cell loss, and

• br Introduction Rhamdia quelen jundi Silurifomes Heptapterid

  2025-01-18

  

  Introduction Rhamdia quelen (jundiá, Silurifomes, Heptapteridae) is a neotropical catfish widely distributed in Central and South America (Silfvergrip, 1996). This species shows high potential for the aquaculture industry, due to an elevated growth rate, good carcass yield, and easy reproduction

• The results of our in

  2025-01-18

  

  The results of our in vivo experiments provide promising evidence that the apelin/APLNR axis is implicated in CCA growth and that targeting this axis with a receptor specific antagonist may help develop effective, tumor directed therapies. Not only do we show decreased proliferation and angiogenesis

• Limitations of this study include the

  2025-01-18

  

  Limitations of this study include the use of HL-1 cardiomyocytes, which show different characteristics than primary cardiomyocytes [56]. Furthermore, sustained TAC in Ampkα1-deficient mice did not favorably influence cardiac function [33]. It must be kept in mind that global Ampkα1-deficiency may af

• Besides above mentioned UV visible and fluorescence spectros

  2025-01-18

  

  Besides above-mentioned UV–visible and fluorescence spectroscopy methods, electron paramagnetic resonance (EPR) spectroscopy, the only analytical method that detect compounds having unpaired electrons known as free radicals, was rarely used in antioxidant capacity measurement (Amarowicz et al., 2004

• ATP-competitive kinase inhibitor Although the earlier studie

  2025-01-18

  

  Although the earlier studies focused on the antioxidant capacity of tocopherols, ascorbic ATP-competitive kinase inhibitor and carotenoids, then it was noticed that phenolic compounds were more powerful than others (Rice-Evans, Miller, & Paganga, 1996). Phenolic compounds, the most numerous and ubi

• Introduction According to Uganda s Ministry of Health

  2025-01-18

  

  Introduction According to Uganda's Ministry of Health (MOH 2012a:91), intermittent preventive treatment (IPT) to avoid malaria during pregnancy is a free preventive service available to all pregnant women without clinical signs and symptoms of malaria, attending prenatal clinics. However, pregnant

• Further validation for a role

  2025-01-18

  

  Further validation for a role in 12/15-LOX pathway in mediating adipocyte function comes from studies revealing a regulatory role of lipocalin-2 on 12/15-LOX activity. Lipocalin-2, a glycoprotein member of the lipocalin superfamily, is a novel abundant adipokine implicated in obesity-mediated inflam

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